新工科背景下智能控制电路项目实践课程改革研究

针对当前智能控制电路项目实践课程存在问题,进行原因分析,并提出引入国际先进的教育模式——OBE模式的"8"字形课程架构,提出了课程设计和教学策略等方面的创新措施。     

Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review

Hollow mesoporous silica nanoparticles (HMSNs) have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties, large specific surface area and facile functionalization, especially made into intelligent drug delivery systems (DDSs) for cancer therapy. HMSNs are employed to transport traditional anti-tumor drugs, which can solve the problems of drugs with instability, poor solubility and lack of recognition, etc., while significantly improving the anti-tumor effect. And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment. Actually, HMSNs-based DDSs have developed relatively mature in recent years. This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS, as well as its degradation, different stimuli-responses, targets and combination therapy. These versatile intelligent nanoparticles show great potential in clinical aspects.     

大涡模拟Smagorinsky模型用于磨粒流精密加工喷嘴的质量控制研究

为研究固液两相磨粒流加工喷嘴小孔过程中的流场分布、涡旋形成规律及涡旋的存在对磨粒流加工的影响机制，采用Smagorinsky亚格子模型对磨粒流加工喷嘴小孔的流道进行大涡数值模拟，并使用磨粒流对变直径喷嘴工件进行加工试验。数值模拟发现磨粒流流体中磨粒与壁面的碰撞与剪切作用随流体的速度增大而增大，同一截面的速度存在速度差，其中还伴随涡旋的存在；通过试验研究发现：经固液两相磨粒流加工后的喷嘴小孔表面质量得到明显提高，喷嘴经过四次不同入口速度的磨粒流加工后大孔处表面粗糙度Ra由1.24 μm降至0.542 μm，小孔处表面粗糙度Ra由1.21 μm降至0.437 μm。结论显示固液两相磨粒流加工技术可有效提高被加工喷嘴工件的内表面质量，加工时同一截面的速度存在速度差，速度差的存在利于涡旋的形成，涡旋的存在利于提高磨粒流加工过程的剪切作用，有助于获得高质量的喷嘴小孔内通道表面。     

安徽省铜陵市铁山头铜矿床地质特征及找矿潜力

铁山头铜矿床处于铜陵矿集区的中东部，属于扬子陆块下扬子凹陷中的铜陵隆起。矿床位于凤凰山矿田北侧，成矿潜力较大。综合研究分析认为：①接触交代作用使得岩体接触带及附近变质形成矽卡岩矿化带；②区内凤凰山岩体（花岗闪长岩）系成矿母岩；③矿体主要赋存于花岗闪长岩与三叠系下统南陵湖组石灰岩接触带上；④矿床成因类型为高—中温热液交代矽卡岩型矿床。     

矿山尾矿资源综合利用现状及前景分析

为提高我国尾矿资源的利用率和利用水平，分析了我国尾矿堆存量大、利用率低、开发利用研发力度不足等严峻现状，指出了问题存在的根源是技术水平不高、国家政策不到位和管理不善、相关矿山企业对尾矿利用重视不够，并针对问题提出了相关建议。     

Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator

Self-assembled peptide hydrogels represent the realization of peptide nanotechnology into biomedical products. There is a continuous quest to identify the simplest building blocks and optimize their critical gelation concentration (CGC). Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest CGC ever reported, almost fourfold lower as compared to that of a large hexadecapeptide previously described, is reported. The dipeptide self-assembles through an unusual and unprecedented two-step process as elucidated by solid-state NMR and molecular dynamics simulation. The hydrogel is cytocompatible and supports 2D/3D cell growth. Conductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit excellent DNA binding. Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipeptide analogues, thus validating the uniqueness of the molecular design which confers useful properties for various potential applications.     

表面润湿性对梯形除雾器分离性能的影响

为解决实际工业中除雾器在高气速时分离效率明显降低的问题，利用除雾器分离实验装置，以水为实验介质，采用电火花线切割技术在叶片表面构建仿生微结构实现表面疏水化，考察了表面润湿性对除雾器分离效率和压降的影响。结果表明，仿生微结构的疏水功能和减阻效应良好，表面液膜的排液速率明显加快。当气速超过5 m/s时，其液膜厚度相对较薄，可有效抑制液滴的二次夹带，提升分离效率。同时，疏水型梯形除雾器内的流场分布较平缓，流动阻力小，总压降约为带钩型梯形除雾器的一半。因此，疏水型梯形除雾器兼具高效率和低阻力特性，综合分离性能最佳。     

用宽带超表面产生阵列贝塞尔光束

通过在空间光调制器（SLM）上加载相位图或通过光刻加工微型圆锥状结构可以产生贝塞尔光束阵列。然而，典型空间光调制器具有比波长大一个数量级的像素尺寸，这限制了相位梯度的可用范围，用光刻法加工的微型锥透镜的顶端不是标准的圆锥，这影响了贝塞尔光束的质量。为了克服这些缺点，将复杂的相位图加载到电介质超表面上，设计了一种可以产生阵列贝塞尔光束（在波长700 nm处，NA=0.3）的超表面器件。该器件可以宽波段工作，其单元结构在波长580~800 nm范围内的偏振转换效率均超过57%。利用时域有限差分算法（FDTD）对该器件（厚度为380 nm，直径仅为40 μm）进行了仿真，所产生的阵列光束都垂直于超表面器件。所提出的阵列贝塞尔光束发生器具有纳米级别的厚度和几十微米的直径，这对于未来的集成光学领域具有很大的应用前景。     

基于多元神经网络融合的分布式资源空间文本分类研究

针对实体产业对科技资源的服务需求,以服务效应作为资源文本分类标准,提出一种基于多元神经网络融合的分布式资源空间文本分类模型。设计了包含词嵌入层、卷积层、双向门控循环单元层、注意力机制层和softmax层的多元神经网络通路;在此基础上采用基于需求—效应—资源分类策略,完成了从定性科技资源需求到定量资源服务效应求解,再到定性科技资源输出的映射变换,重点解决了分布式科技资源局部和全局语义特征形式多样、文本长距离依赖特征显著、重要资源信息难以准确识别的问题,进而从分布式科技资源空间中快速准确地获取效应知识,提升实体产业产品研发效率和创新能力;通过万方专利科技资源数据集验证了所提方法的可行性和有效性,为更加全面地挖掘资源文本特征和按需服务实体产业提供了一种新的思路和手段。     

Investigation on the anti-reduction mechanism of Ti4+ in high dielectric constant system Ca0.9La0.067TiO3 by doping with Al2O3

Ca_0.9La_0.067TiO₃ (abbreviated as CLT) ceramics doped with different amount of Al₂O₃ were prepared via the solid state reaction method. The anti-reduction mechanism of Ti⁴⁺ in CLT ceramics was carefully investigated. X-ray diffraction (XRD) was used to analyze the phase composition and lattice structure. Meanwhile, the Rietveld method was taken to calculate the lattice parameters. X-ray photoelectron spectroscopy (XPS) was employed to study the valence variation of Ti ions in CLT ceramics without and with Al₂O₃. The results showed that Al³⁺ substituted for Ti⁴⁺ to form solid solution and the solid solubility limit of Al³⁺ is near 1.11 mol%. Furthermore, the reduction of Ti⁴⁺ in CLT ceramics was restrained by acceptor doping process and the Q × f values of CLT ceramics were improved significantly. The CLT ceramic doped with 1.11 mol% Al₂O₃ exhibited good microwave dielectric properties: ε_r = 141, Q × f = 6848 GHz, τ_f = 576 ppm/°C.